Hyaluronic acid injectable fillers are the most widely used soft tissue fillers to treat facial volume deficits, providing long-term facial aesthetic enhancement outcomes for the signs of aging and/or facial contouring.(1)

Soft tissue fillers are a minimally invasive aesthetic medicine procedure used to improve or create volume, to remodel the contours of the face and fill in wrinkles and deep folds.(2)

Common areas to inject fillers are in the face, neck and décolleté, this results in a fuller, smoother and more youthful appearance. Fillers are among the most popular aesthetic medical procedures because they carry immediate results, minimal risks and little recovery time.(2)

Their main indications are the filling of wrinkles and folds, and the correction of soft tissue loss due to disease or age. Increasingly, fillers are used for volume replacement and enhancement procedures, this includes cheek and chin augmentation, tear trough correction, nose reshaping, mid-facial volumisation, lip enhancement, neck and décolleté rejuvenation and the correction of facial asymmetry.


Origin and composition

Fillers may be classified depending on their source as:

  • autologous (e.g., fat, cultured human fibroblasts).(2,4)
  • collagen (bovine-derived, human-derived from tissue culture). Collagen is a naturally occurring protein that adds strength and structure to the skin.(2,4)
  • hyaluronic acid (HA) (non-animal stabilised or viscoelastic HA from bacterial fermentation). Like collagen, hyaluronic acid is a naturally occurring substance and primarily used to promote fullness and volume as it attracts water.(2,4)
  • synthetic or pseudo-synthetic implants (silicone, polymethacrylate microspheres, poly-L-lactic acid, calcium hydroxylapatite microspheres suspended in aqueous polysaccharide gel, alkyl-imide gel polymer).(2,4)


Depending on their permanence in the body, fillers can be classified as temporary, semi-permanent, and permanent. The first two classes have a different time of duration in the tissue due to the reabsorption, while the permanent fillers are not absorbable.

  • Temporary fillers stay in the tissue for less than a year; they have a temporary effect because they contain materials that are absorbed by the body over time(3). Examples are: fillers based on collagen, hyaluronic acid and calcium hydroxylapatite(2).
  • Semi-permanent fillers stay in the tissue for up to 1–2 years.(3) Longer-lasting fillers typically contain substances such as the absorbable synthetic filler known as poly-L-lactic acid.(2)
  • Permanent fillers are substances that remain in the tissue more than two years.(3) Permanent fillers are made of polymethylmethacrylate (PMMA), which are microspheres that are not absorbed by the body.(2)

DefinisseTM Fillers

Everyday is our moment

Life is continuous change. We learn, we grow, we build families and careers, we pursue our dreams, we move from one place to another, we experience. So does our skin, which lives and changes with us.

What matters, is feeling good with ourselves.
Every moment of the day.

The best technology
for your best self

Thanks to the innovative XTR™ Technology in hyaluronic acid filler, the new Definisse™ Filler range helps to improve facial volume distribution and ultimately balances facial contouring.(5)

A smile to the future

We all deserve to look at time with the right confidence.

Definisse™ Filler range provides immediate and excellent results.5 It can be used to add volume to different areas of the face where needed and to smooth lines and wrinkles. Speak to a physician today about your aesthetic needs.

It is the beauty of a moment.

Immediate and Excellent
Clinical Results1

A stable and elastic
3D matrix:


DefinisseTM touch filler

+ Lidocaine

  • Definisse™ touch filler + Lidocaine intended use is  to create volume in order to correct wrinkles and folds, to correct moderate to severe nasolabial folds, and to improve lip volume to treat signs of ageing.(6)
  • Injections in the periorbital region (including tear trough, upper periorbit and eyelids), glabella and nasal alae require appropriate training.

Clinical Case


Photos courtesy of Dr. Giovanni Salti.

DefinisseTM restore filler

+ Lidocaine

  • Definisse™ restore filler + Lidocaine intended purpose  is to create volume in order to correct wrinkles and folds, and to correct moderate to severe nasolabial folds and  to treat signs of ageing.7
  • This device must only be used by doctors who have received specific training on the injection technique for filling wrinkles and restoring volume to the face. Injections into periorbital region (including tear trough, upper periorbit and eyelids), glabella and nasal alae require appropriate training.

Clinical Case


Photos courtesy of Dr. Adriano Santorelli.

DefinisseTM core filler

+ Lidocaine

  • Definisse™ core filler + Lidocaine intended purpose is to restore facial volume in order to correct moderate to severe midface volume deficit and to treat signs of ageing.8

Clinical Case


Photos courtesy of Dr. Giovanni Salti.

(1) Pierre S, Liew S, Bernardin A. Basics of dermal filler rheology. Dermatol Surg. 2015 Apr;41 Suppl 1: S120-6. doi: 10.1097/DSS.0000000000000334.
(2) The American Society for Aesthetic Plastic Surgery. Fillers. [online] Available at: [accessed March 2017].
(3) Vedamurthy al. Dermal fillers: tips to achieve successful outcomes. J Cutan Aesthet Surg 2008; 1(2): 64–67.
(4) Ganceviciene al. Skin anti-aging strategies. Dermatoendocrinol 2012 Jul 1; 4(3): 308–319.
(5) Salti G. Meet the innovative XTR™ (eXcellent Three-dimensional Reticulation) technology of Definisse™ Filler. PRIME Journal Jan/Feb
(6) Definisse™ touch filler + Lidocaine, Information For Use
(7) Definisse™ restore filler + Lidocaine, Information For Use.
(8) Definisse™ core filler + Lidocaine, Information For Use.

IR-WEB-73-2021 IE 21067   |   Date of Use October 2021